Preparation, characterization, and in vitro release of ketoprofen. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Preparation and characterization of gastroretentive floating. The hollow microspheres were found to be regular in shape and highly porous. The preparation of nc microspheres and bunena modified nc microspheres. Bharadia, vikram pandya and darshan modi department of pharmaceutics, b. The method used for the preparation of microspheres may be the reason for the high drug entrapment efficiency. Microspheres can be manufactured from various natural and synthetic materials. The addition of hollow spheres to fiberglass reinforced plastics frp, epoxy, compounds, and urethane castings can provide weight reduction cost savings. Ethyl cellulose and hydroxypropyl methyl cellulose buoyant. Psl completes full microsphere formulation production lines.
Basic gastrointestinal tract physiology anatomically, the stomach is divided into three re. Solid biodegradable microspheres incorporating a drug. The addition of hollow spheres to fiberglass reinforced plastics frp, epoxy, compounds, and urethane. The assembly process was controlled by specific chemical amine. The floating microspheres were collected by decantation, while the non floating microspheres were discarded along with any polymer precipitates. Qcel hollow spheres and extendospheres hollow spheres products offer formulators flexibility in polymer composites. Novel ow emulsion solvent diffusion technique was used for preparation of microspheres of ranolazine by using various polymers such as hpmc hydroxyl propyl methyl cellulose, ethyl cellulose. The microspheres exhibited good mucoadhesive property in the in vitro washoff test and also showed a high percentage drug entrapment efficiency. Microspheres are small and have large surfacetovolume ratio. Floating microspheres provide a constant and prolonged therapeutic effect which will reduce dosing frequency. Pectin and chitosan microsphere preparation via a wateroil. To assess drug content, 20 mg of m weighed and dissolved in 0.
Powder systems limited psl, an international awardwinning manufacturer of filtration, drying and high containment isolators for the pharmaceutical and biopharmaceutical industries, recently delivered several aseptic microsphere formulation process facilities in asia and usa. Research paper preparation and characterization of. The microspheres of both biopolymers were prepared by an emulsion and solvent evaporation method. Evaluation of mucoadhesive properties of chitosan microspheres. Biodegradablebiocompatible polymers, eudragit l100 and polyvinyl pyrrolidone, were. Microspheres for intranasal applications are usually prepared using biocompatible materials, such as starch, albumin, dextran, and gelatin 33,77. Jan 22, 2014 contents of the powerpoint on formulation and evaluation of microspheres include. The entrapment largely depends on the method of preparation and nature of the drug or polymer monomer if used. The grind number increases as 3m ceramic microspheres w210 and w410 are added to the grind and minex, duramite and calcined kaolin clay are removed. Sodium alginate alone or in combination with guargum and the gas forming agent sodium carbonate were dispersed in the purified water to form a homogeneous polymer mixture.
The preparation of nc microspheres and bunena modified nc. Microspheres are characteristically free flowing powders having particle size ranging from 1. Onepot preparation of polymer microspheres having wrinkled hard. Venkata naga jyothi, microencapsulation technique, factors influencing. Optimization of methods for the preparation of famotidine. Keywords serratiopeptidase, cholic acid, chitosan mucoadhesive microspheres 1. The percentage yield of floating microspheres was varied according to concentration of polymer. Formulation and evaluation of mucoadhesive glipizide microspheres. The active component can be loaded by means of the physical entrapment, chemical linkage and surface adsorption. Contents of the powerpoint on formulation and evaluation of microspheres include. Cospheric is a global leader in manufacturing and distribution of precision nanospheres, microspheres, and larger precision spherical particles. A 3 2 full factorial design was employed to study the effect of independent variables, polymertodrug ratio x 1, and stirring speed x 2 on dependent variables percentage mucoadhesion, t 80. Pristine and modified hollow microparticles were characterized by fieldemission electron microscopy, transmission electron microscopy, xray diffraction, xray photoelectron spectroscopy, ftir and. Hollow magnetite microspheres have been synthesized by a simple process through a templatefree hydrothermal approach.
Preparation and invitro evaluation of metformin microspheres. Sustained release microspheres of ropinirole hydrochloride acta. Preparation of hollow magnetite microspheres and their. Solid and hollow microspheres vary widely in density and, therefore, are used for different applications. Result also showed that longer the size of microsphere more the ability to float. Density marker beads are small colored microspheres of known mass density that are used for calibrating density gradients and determining density in gradient columns. Density gradient are often used for separation and purification of cells, viruses and subcellular particles. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products.
Due to microscopic size, microspheres can be used alone or incorporated in other drug delivery systems and are suitable for various routes of application. These, however, do not always meet the exacting standards which modern manufacturing. The percentage of microspheres was calculated by the following equation %floating microspheres weight of floating microspheres initial weight of floating microspheres. Relying on microencapsulation process technologies developed inhouse and through technology partnerships, innocore is capable of producing injectable microsphere formulations with controlled particle size typically 2050 micron that are suitable for sustained release of active. Microspheres market growth, trends, and forecast 2020 2025 the market is segmented by raw material glass, polymer, ceramic, fly ash, metallic, and other raw materials, type hollow and solid, application automotive, aerospace, cosmetics, oil and gas, paints and coatings, medical technology, composites, and other applications, and geography asiapacific, north america, europe, south. Mar 31, 2016 psl completes full microsphere formulation production lines. Pharmatutorart1266 introduction between 1940s and 1960s, the concept of micro encapsulation technology began as an alternative means of delivering drugs. Microspheres prepared with ethocel 20 cps and hpmc k100m showed more sustained release when compared to microspheres prepared with hpmc k100lv. Process for preparation of microcapsules and microspheres 67.
For example, by taking advantage of the characteristics of microspheres, beyond the basic benefits, the microspheres could provide a larger surface area and. Formulation and evaluation of telmisartan microspheres by. The invitro buoyancy test was carried out to investigate buoyancy of prepared microspheres. Glass microspheres, polymer microspheres, metal microspheres, and ceramic microspheres are commercially available. Preparation of floating microspheres floating microspheres containing ranolazine were prepared emulsion solvent diffusionevaporation technique using ec, hpmc, and eudragit l100 polymer in ratio 1. Various microsphere preparation methods were reported which can be used to incorporate drug in microspheres. The collected microspheres were dried in desiccators over night. In continued quest for the more refined system, in 1980s polymermembrane technology came to be known at forefront. The microspheres were dried in an oven at 50 0c for 2h, weighed and then stored in a desiccator at room temperature till further use. Generally, a set of several density marker beads covering a range of densities used.
Hollow microspheres were surface modified by coating with a silica nanolayer. Preparation and characterization of microspheres for. Preparation and evaluation of floating microspheres of. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritics characters, floating behaviour and in vitro drug release. Microspheres market growth, trends, and forecast 2020. Microspheres are manufactured in both solid and hollow form. References powders and granulates freeflowing powders and granulates are needed for a variety of industrial processes. Microspheres, microbeads and microparticles for scientific. One such approach is the preparation of a device that remains buoyant in the stomach contents due to its lower density than that of the gastric fluids.
Development and evaluation of floating microspheres of. Preparation of silicapolymer hybrid microspheres and the corresponding hollow polymer microspheres with functional groups guangyu liu, longyu li, xinlin yang, zhao dai polymers for advanced technologies 2008 19 10. They are spherical free flowing particles consisting of proteins or synthetic polymers. The percentage yield and entrapment efficiency were found to be in range of 86. In such cases, the release will occur from compacts in the tablet formulation.
However, their toxicityirritancy on the nasal mucosa due to the presence of a variety of polymersexcipients used in the preparation of microspheres must be critically evaluated. The development and characterization of starch microspheres. Hollow microspheres are used as additives to lower the density of a material. Adding 3m ceramic microspheres w610 to the grind mixture slightly decreases the hegman grind number. Colloidal assembly was performed using polymer nanoparticles. Introduction microspheres can be defined as solid, spherical, free flowing, smooth surface particles ranging in size from 1 to 4m. Formulation and evaluation of floating microspheres of. Patel institute of pharmaceutical education and research, shirpur dhule maadhuri. Grdfs, fdds, hollow microspheres introduction the goal of any drug delivery system is to provide a. Preparation and characterization of gastroretentive. The microspheres can be prepared by using any of the several techniques given below but choice of the technique mainly depends on the nature of the polymer used, the drug, the intended use and the.
Microspheres are solid spherical particles ranging in size from 1m. The interfacial properties of microspheres are extremely important, often indicating their activity. The zeta potential in turn was found to be dependent upon the method of preparation of microspheres. Further, the process of targeting and site specific delivery with absolute accuracy can be achieved by attaching bioactive molecule to liposome, bioerodable polymer, implants, monoclonal antibodies and various particulate carriers e. The preparation of nc microspheres and bunena modified. Microsphere can be used for the controlled release of drugs, vaccines, antibiotics, and hormones. Journal of controlled release, 16 1991 279290 1991 eisevier science publishers b. Apr 10, 2012 hollow magnetite microspheres have been synthesized by a simple process through a templatefree hydrothermal approach. Interfacial polymerization technique when two reactive monomers are dissolved in immiscible solvents, the monomers diffuse to the oil water interface where they react to form a polymeric membrane that envelopes dispersed phase. Further, the process of targeting and site specific delivery with absolute accuracy can be achieved by. During the preparation of microspheres or after the formation of microspheres by incubating. To prepare and evaluate metformin microspheres for prolonged release. Formulation, optimization and evaluation of mucoadhesive.
Preparation of floating microspheres floating microspheres were prepared by. Banapure2 1department of pharmaceutics, smbt college of pharmacy, dhamangaon, nashik 2h. Polymer microspheres with wrinkled hard surfaces composed of selfassembled silica nanoparticles were prepared via suspension polymerization. Preparation of ritonavir floating microspheres 5 the floating microspheres containing ritonavir were prepared by orifice ionic gelation technique. Gastroretentive floating microspheres are lowdensity systems that have. In selection of drug to polymer ratio total three ratios were tried and it table 2. Curcumin was a gift sample from krish enteprizes, mumbai, india. The method employed was efficient for the preparation. The development and characterization of starch microspheres prepared by a sonochemical method for the potential drug delivery of insulin. The formulations f 1 to f 5 floating ability is shown in table 2.
Microencapsulation by the solvent evaporation method is a complex. At the lower end of their size range they have colloidal properties. The procedure was repeated until the microspheres reached constant weight equilibrium water uptake. Characterization and release kinetics of microspheres and. Sep 30, 2014 formulation and evaluation of microspheres 1. The collected microspheres were dried in desiccators.
The prepared microspheres with a size ranging from 75 to 600 m were collected and weighed. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. Polymer concen tration and polymerdrug ratio were analyzed for their influence on microsphere properties. Injectable, biodegradable microspheres form a successful system for parenteral drug delivery. Pristine and modified hollow microparticles were characterized by fieldemission electron microscopy, transmission electron microscopy, xray diffraction, xray photoelectron. Scientists and engineers worldwide rely on us as a proven source to fulfill their needs for microparticles in narrow size ranges, wide selection of colors, densities, properties and formulations. Octoberdecember 20 research article ijpsn322rajkumar.
The microspheres are free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature. Preparation and characterization of gliclazide incorporated. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation before the drug is incorporated. After 24 hr the swollen microspheres were taken out and immediately weighed after removal of excess of water by using a blotter. In this method famotidine and hpmc, ethyl cellulose was dissolved in dichloromethane and dimethylformamide 1. This gastrointestinal transit controlled preparation is designed to float on. Formulation and evaluation of mucoadhesive glipizide. Polyurethene, ureaformaldehyde, pmma, polystyrene 10 15 20 ncy % 0. Microspheres methods for preparation of microspheres.
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